Version 5.4
Mus musculus Gene: Slc2a4
Summary
InnateDB Gene IDBG-192874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc2a4
Gene Name solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms Glut-4; Glut4
Species Mus musculus
Ensembl Gene ENSMUSG00000018566
Encoded Proteins
IDBP-192878
solute carrier family 2 (facilitated glucose transporter), member 4
IDBP-719153
IDBP-717336
IDBP-717036
IDBP-718823
IDBP-718100
IDBP-717258
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181856:
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69942539-69948188
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000018710 ENSMUSP00000018710
ENSMUST00000141837 ENSMUSP00000136806
ENSMUST00000152487 ENSMUSP00000136504
ENSMUST00000142500 ENSMUSP00000137463
ENSMUST00000135437 ENSMUSP00000137092
ENSMUST00000178809
ENSMUST00000179298 ENSMUSP00000136726
ENSMUST00000178363 ENSMUSP00000136455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0005360 insulin-responsive hydrogen:glucose symporter activity
GO:0005515 protein binding
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0010021 amylopectin biosynthetic process
GO:0015758 glucose transport
GO:0032869 cellular response to insulin stimulus
GO:0042593 glucose homeostasis
GO:0045471 response to ethanol
GO:0050873 brown fat cell differentiation
GO:0055085 transmembrane transport
GO:0071456 cellular response to hypoxia
GO:0071470 cellular response to osmotic stress
Cellular Component
GO:0005768 endosome
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030136 clathrin-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030315 T-tubule
GO:0030659 cytoplasmic vesicle membrane
GO:0031982 vesicle
GO:0032593 insulin-responsive compartment
GO:0042383 sarcolemma
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181856
View Gene Order
ENSBTAG00000009190
Not yet available
Pathways
NETPATH
REACTOME
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_189085
Disease pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_209837
Membrane Trafficking pathway
REACT_188937
Metabolism pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_188576
Developmental Biology pathway
REACT_206357
Facilitative Na+-independent glucose transporters pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04910
Insulin signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_19343
Facilitative Na+-independent glucose transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_11123
Membrane Trafficking pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_203892
Hexose transport pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_203157
Facilitative Na+-independent glucose transporters pathway
REACT_204270
Glucose transport pathway
REACT_211129
Glycogen storage diseases pathway
REACT_219139
Metabolism pathway
REACT_212003
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_207087
Disease pathway
REACT_220844
Developmental Biology pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
arf6_traffickingpathway
Arf6 trafficking events
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL J3QMU2
UniProt Splice Variant
Entrez Gene 20528
UniGene Mm.10661 Mm.473333
RefSeq NM_009204 XM_006532653 XM_006532654 XM_006537144 XM_006537145
OMIM
CCDS CCDS36201
HPRD
IMGT
MGI ID MGI:95758
MGI Symbol Slc2a4
EMBL AL596185
GenPept
RNA Seq Atlas 20528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca