Homo sapiens Gene: SLC2A4
Summary
InnateDB Gene IDBG-24140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC2A4
Gene Name solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms GLUT4;
Species Homo sapiens
Ensembl Gene ENSG00000181856
Encoded Proteins
solute carrier family 2 (facilitated glucose transporter), member 4
solute carrier family 2 (facilitated glucose transporter), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7281667-7288257
Strand Forward strand
Band p13.1
Transcripts
ENST00000317370 ENSP00000320935
ENST00000424875 ENSP00000396887
ENST00000572485 ENSP00000461086
ENST00000570783 ENSP00000459056
ENST00000571308 ENSP00000459864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 39 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0005515 protein binding
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008645 hexose transport
GO:0010021 amylopectin biosynthetic process
GO:0015758 glucose transport
GO:0032869 cellular response to insulin stimulus
GO:0042593 glucose homeostasis
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046323 glucose import
GO:0050873 brown fat cell differentiation
GO:0055085 transmembrane transport
GO:0061024 membrane organization
GO:0071456 cellular response to hypoxia
GO:0071470 cellular response to osmotic stress
Cellular Component
GO:0005768 endosome
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030136 clathrin-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030315 T-tubule
GO:0031982 vesicle
GO:0032593 insulin-responsive compartment
GO:0042383 sarcolemma
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
REACTOME
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Myoclonic epilepsy of Lafora pathway
Facilitative Na+-independent glucose transporters pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Translocation of GLUT4 to the plasma membrane pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Disease pathway
Glycogen storage diseases pathway
Membrane Trafficking pathway
KEGG
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
Arf6 trafficking events
Insulin-mediated glucose transport
Cross-References
SwissProt P14672
TrEMBL F5H081 I3L1S2 I3L2R4 Q05BQ3
UniProt Splice Variant
Entrez Gene 6517
UniGene Hs.380691 Hs.712449
RefSeq NM_001042
HUGO HGNC:11009
OMIM 138190
CCDS CCDS11097
HPRD
IMGT
EMBL AC003688 BC034387 BC069615 BC069621 BC113592 BC126164 CH471108 M20747 M91463 X58489
GenPept AAA52569 AAA59189 AAH34387 AAH69615 AAH69621 AAI13593 AAI26165 CAA41399 EAW90227
RNA Seq Atlas 6517