InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC2A4

Summary

InnateDB Gene

IDBG-24140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A4

Gene Name

solute carrier family 2 (facilitated glucose transporter), member 4

Synonyms

GLUT4

Species

Homo sapiens

Ensembl Gene

ENSG00000181856

Encoded Proteins

IDBP-24144

solute carrier family 2 (facilitated glucose transporter), member 4

IDBP-365301

solute carrier family 2 (facilitated glucose transporter), member 4

IDBP-758835

IDBP-759330

IDBP-758853

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7281667-7288257

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000317370	ENSP00000320935
ENST00000424875	ENSP00000396887
ENST00000572485	ENSP00000461086
ENST00000570783	ENSP00000459056
ENST00000571308	ENSP00000459864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	39 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0005515	protein binding
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0055056	D-glucose transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008645	hexose transport
GO:0010021	amylopectin biosynthetic process
GO:0015758	glucose transport
GO:0032869	cellular response to insulin stimulus
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046323	glucose import
GO:0050873	brown fat cell differentiation
GO:0055085	transmembrane transport
GO:0061024	membrane organization
GO:0071456	cellular response to hypoxia
GO:0071470	cellular response to osmotic stress

Cellular Component

GO:0005768	endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030136	clathrin-coated vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0030315	T-tubule
GO:0031982	vesicle
GO:0032593	insulin-responsive compartment
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome