Mus musculus Gene: Akap13
Summary
InnateDB Gene IDBG-193054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap13
Gene Name A kinase (PRKA) anchor protein 13
Synonyms 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; AKAP-Lbc; BRX; Ht31; LBC; PROTO-LB; PROTO-LBC;
Species Mus musculus
Ensembl Gene ENSMUSG00000066406
Encoded Proteins
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170776:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:75455534-75754609
Strand Forward strand
Band D1
Transcripts
ENSMUST00000094307 ENSMUSP00000091865
ENSMUST00000147005 ENSMUSP00000117686
ENSMUST00000136989
ENSMUST00000141666
ENSMUST00000125771 ENSMUSP00000118138
ENSMUST00000154740 ENSMUSP00000121355
ENSMUST00000151560
ENSMUST00000141486
ENSMUST00000141288
ENSMUST00000137959 ENSMUSP00000116573
ENSMUST00000134001
ENSMUST00000132656
ENSMUST00000166315 ENSMUSP00000129784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004691 cAMP-dependent protein kinase activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0032947 protein complex scaffold
GO:0046872 metal ion binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0045859 regulation of protein kinase activity
GO:0051168 nuclear export
GO:1900169 regulation of glucocorticoid mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
TSLP pathway
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID BIOCARTA
Rho-selective guanine exchange factor akap13 mediates stress fiber formation [Biocarta view]
PID NCI
PAR1-mediated thrombin signaling events
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.216107 Mm.408232 Mm.414975
RefSeq NM_029332 XM_006541250 XM_006541251 XM_006541252 XM_006541254 XM_006541256 XM_006541257 XM_006541258 XM_006541259
OMIM
CCDS CCDS52276
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas