Homo sapiens Gene: AKAP13
Summary
InnateDB Gene IDBG-28095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP13
Gene Name A kinase (PRKA) anchor protein 13
Synonyms AKAP-13; AKAP-Lbc; ARHGEF13; BRX; c-lbc; HA-3; Ht31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC;
Species Homo sapiens
Ensembl Gene ENSG00000170776
Encoded Proteins
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
A kinase (PRKA) anchor protein 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:85380571-85749358
Strand Forward strand
Band q25.3
Transcripts
ENST00000361243 ENSP00000354718
ENST00000394518 ENSP00000378026
ENST00000394510 ENSP00000378018
ENST00000560571
ENST00000559362 ENSP00000453768
ENST00000560302 ENSP00000453634
ENST00000560256 ENSP00000453620
ENST00000558166 ENSP00000452622
ENST00000558811 ENSP00000452698
ENST00000560340 ENSP00000483091
ENST00000560676 ENSP00000481485
ENST00000560579 ENSP00000477780
ENST00000559486 ENSP00000453205
ENST00000560957
ENST00000558092
ENST00000557852 ENSP00000480789
ENST00000560482
ENST00000559278
ENST00000558644
ENST00000559820
ENST00000558009
ENST00000559391
ENST00000560185
ENST00000612418 ENSP00000482058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004691 cAMP-dependent protein kinase activity
GO:0004871 signal transducer activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0032947 protein complex scaffold
GO:0046872 metal ion binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007264 small GTPase mediated signal transduction
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045859 regulation of protein kinase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051168 nuclear export
GO:0097190 apoptotic signaling pathway
GO:1900169 regulation of glucocorticoid mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TSLP pathway
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID BIOCARTA
Rho-selective guanine exchange factor akap13 mediates stress fiber formation [Biocarta view]
PID NCI
PAR1-mediated thrombin signaling events
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.459211 Hs.608041 Hs.608755 Hs.619023 Hs.741394
RefSeq NM_001270546 NM_006738 NM_007200 XM_005254846 XM_005254847 XM_005254848 XM_005254854 XM_005254855 XM_005254856
HUGO
OMIM
CCDS CCDS32319 CCDS32320 CCDS73778
HPRD 05253
IMGT
EMBL
GenPept
RNA Seq Atlas