InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ephb1

Summary

InnateDB Gene

IDBG-193780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb1

Gene Name

Eph receptor B1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032537

Encoded Proteins

IDBP-193782

Eph receptor B1

IDBP-193784

Eph receptor B1

IDBP-790080

Eph receptor B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154928:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:101922128-102354693

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035129	ENSMUSP00000035129
ENSMUST00000085169	ENSMUSP00000082261
ENSMUST00000149800	ENSMUSP00000139470

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022008	neurogenesis
GO:0030010	establishment of cell polarity
GO:0031290	retinal ganglion cell axon guidance
GO:0031589	cell-substrate adhesion
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051965	positive regulation of synapse assembly
GO:0060326	cell chemotaxis
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome