Mus musculus Gene: Cat
Summary
InnateDB Gene IDBG-193911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cat
Gene Name catalase
Synonyms 2210418N07; Cas-1; Cas1; Cs-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000027187
Encoded Proteins
catalase
catalase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121691:
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer\'s disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:103453849-103485160
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000028610 ENSMUSP00000028610
ENSMUST00000111168 ENSMUSP00000106798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004046 aminoacylase activity
GO:0004096 catalase activity
GO:0005102 receptor binding
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0006641 triglyceride metabolic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0008203 cholesterol metabolic process
GO:0009060 aerobic respiration
GO:0009650 UV protection
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027 hemoglobin metabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033197 response to vitamin E
GO:0042697 menopause
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051781 positive regulation of cell division
GO:0055093 response to hyperoxia
GO:0055114 oxidation-reduction process
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005764 lysosome
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
Purine metabolism pathway
Metabolism pathway
Metabolism of nucleotides pathway
Purine catabolism pathway
KEGG
Tryptophan metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cellular responses to stress pathway
Purine metabolism pathway
Purine catabolism pathway
Detoxification of Reactive Oxygen Species pathway
Metabolism of nucleotides pathway
Metabolism pathway
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
Metabolism of nucleotides pathway
Purine metabolism pathway
Metabolism pathway
Purine catabolism pathway
KEGG
Tryptophan metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
The igf-1 receptor and longevity [Biocarta view]
PID NCI
FoxO family signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4215 Mm.466847 Mm.490469
RefSeq NM_009804 XM_006498624
OMIM
CCDS CCDS16478
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas