Homo sapiens Gene: PAIP1
Summary
InnateDB Gene IDBG-19493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAIP1
Gene Name poly(A) binding protein interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172239
Encoded Proteins
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
poly(A) binding protein interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43526267-43557758
Strand Reverse strand
Band p12
Transcripts
ENST00000338972 ENSP00000339622
ENST00000306846 ENSP00000302768
ENST00000436644 ENSP00000387729
ENST00000514816 ENSP00000426089
ENST00000514514 ENSP00000425084
ENST00000504639 ENSP00000422084
ENST00000511321 ENSP00000425675
ENST00000508537 ENSP00000425736
ENST00000504075 ENSP00000427410
ENST00000515338 ENSP00000425406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0008494 translation activator activity
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006413 translational initiation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0045727 positive regulation of translation
GO:0048255 mRNA stabilization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Deadenylation-dependent mRNA decay pathway
Deadenylation of mRNA pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.482038 Hs.596048 Hs.641972 Hs.649212
RefSeq NM_006451 NM_182789 NM_183323 XM_005248230
HUGO
OMIM
CCDS CCDS3947 CCDS3948 CCDS47204
HPRD 05539
IMGT
EMBL
GenPept
RNA Seq Atlas