Mus musculus Gene: Atp5b
Summary
InnateDB Gene IDBG-196497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp5b
Gene Name ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025393
Encoded Proteins
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110955:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128083273-128090391
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026459 ENSMUSP00000026459
ENSMUST00000127439
ENSMUST00000139295
ENSMUST00000126040
ENSMUST00000124993
ENSMUST00000144918
ENSMUST00000123803
ENSMUST00000126751
ENSMUST00000125992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042288 MHC class I protein binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0006200 ATP catabolic process
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0015986 ATP synthesis coupled proton transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process
GO:0051453 regulation of intracellular pH
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0042645 mitochondrial nucleoid
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Metabolism of proteins pathway
Mitochondrial protein import pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Transcriptional activation of mitochondrial biogenesis pathway
Mitochondrial biogenesis pathway
Formation of ATP by chemiosmotic coupling pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial biogenesis pathway
Formation of ATP by chemiosmotic coupling pathway
Metabolism of proteins pathway
Transcriptional activation of mitochondrial biogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Mitochondrial protein import pathway
Formation of ATP by chemiosmotic coupling pathway
Mitochondrial protein import pathway
Transcriptional activation of mitochondrial biogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Metabolism of proteins pathway
Metabolism pathway
Mitochondrial biogenesis pathway
Organelle biogenesis and maintenance pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.238973 Mm.405980 Mm.440753 Mm.441460
RefSeq NM_016774
OMIM
CCDS CCDS24259
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas