Homo sapiens Gene: ATP5B
Summary
InnateDB Gene IDBG-41395.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5B
Gene Name ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Synonyms ATPMB; ATPSB; HEL-S-271;
Species Homo sapiens
Ensembl Gene ENSG00000110955
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56638175-56646068
Strand Reverse strand
Band q13.3
Transcripts
ENST00000262030 ENSP00000262030
ENST00000548474
ENST00000551182
ENST00000547808
ENST00000547250
ENST00000551020 ENSP00000446677
ENST00000550162
ENST00000552959 ENSP00000446489
ENST00000551570 ENSP00000448428
ENST00000553007 ENSP00000447571
ENST00000548647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 117 [view]
Protein-Protein 111 [view]
Protein-DNA 3 [view]
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0022857 transmembrane transporter activity
GO:0042288 MHC class I protein binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0006091 generation of precursor metabolites and energy
GO:0006200 ATP catabolic process
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0015986 ATP synthesis coupled proton transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0046034 ATP metabolic process
GO:0051453 regulation of intracellular pH
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0042645 mitochondrial nucleoid
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial biogenesis pathway
Formation of ATP by chemiosmotic coupling pathway
Metabolism of proteins pathway
Transcriptional activation of mitochondrial biogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Mitochondrial protein import pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P06576
TrEMBL F8VPV9 F8W079 F8W0P7 H0YI37 Q0QEN7 V9HW31
UniProt Splice Variant
Entrez Gene 506
UniGene Hs.637090
RefSeq NM_001686
HUGO HGNC:830
OMIM 102910
CCDS CCDS8924
HPRD
IMGT
EMBL AC090681 AK291085 BC016512 CH471054 D00022 DQ403107 FJ224288 M19482 M19483 M27132 X03559 X05606
GenPept AAA51808 AAA51809 AAH16512 ABD77240 ACI45980 BAA00016 BAF83774 CAA27246 CAA29095 EAW96952
RNA Seq Atlas 506