Homo sapiens Gene: HDAC11
Summary
InnateDB Gene IDBG-19657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC11
Gene Name histone deacetylase 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163517
Encoded Proteins
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
histone deacetylase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MIR145 directly targets HDAC11 to promote IL10 expression in TLR4-triggered macrophages.
Entrez Gene
Summary This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:13479724-13506424
Strand Forward strand
Band p25.1
Transcripts
ENST00000295757 ENSP00000295757
ENST00000402259 ENSP00000384706
ENST00000402271 ENSP00000384123
ENST00000404040 ENSP00000385475
ENST00000404548 ENSP00000385528
ENST00000405025 ENSP00000384019
ENST00000405478 ENSP00000385252
ENST00000433119 ENSP00000412514
ENST00000425430 ENSP00000399792
ENST00000458642 ENSP00000405403
ENST00000418189 ENSP00000411792
ENST00000437379 ENSP00000395188
ENST00000434848 ENSP00000398651
ENST00000416248 ENSP00000402298
ENST00000455904 ENSP00000396122
ENST00000446613 ENSP00000401487
ENST00000475818
ENST00000522202 ENSP00000429794
ENST00000487585
ENST00000498532
ENST00000495099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 135 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008152 metabolic process
GO:0014003 oligodendrocyte development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0045087 innate immune response (InnateDB)
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by HDAC Class II
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.404802 Hs.620910
RefSeq NM_001136041 NM_024827 XM_005265491
HUGO
OMIM
CCDS CCDS2615 CCDS46760
HPRD 09146
IMGT
EMBL
GenPept
RNA Seq Atlas