Mus musculus Gene: Clic4
Summary
InnateDB Gene IDBG-196825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clic4
Gene Name chloride intracellular channel 4 (mitochondrial)
Synonyms D0Jmb3; mc3s5; mtCLIC; TU-74;
Species Mus musculus
Ensembl Gene ENSMUSG00000037242
Encoded Proteins
chloride intracellular channel 4 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169504:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:135213969-135272814
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000037099 ENSMUSP00000041453
ENSMUST00000143370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006821 chloride transport
GO:0007035 vacuolar acidification
GO:0009566 fertilization
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0034765 regulation of ion transmembrane transport
GO:0035264 multicellular organism growth
GO:0044070 regulation of anion transport
GO:0048754 branching morphogenesis of an epithelial tube
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0071277 cellular response to calcium ion
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0030659 cytoplasmic vesicle membrane
GO:0034707 chloride channel complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9QYB1
TrEMBL Q3U8I1 Q543N5
UniProt Splice Variant
Entrez Gene 29876
UniGene Mm.257765 Mm.412244 Mm.473864
RefSeq NM_013885
OMIM
CCDS CCDS18783
HPRD
IMGT
MGI ID MGI:1352754
MGI Symbol Clic4
EMBL AF102578 AK031211 AK049191 AK150993 AK151504 AK152209 AK152273 AK153432 AK155826 AK159402 AK160856 AK166794 AK169376 AK169834 AK170942 AK171243 AK172026 AK172516 AK172660 BC046384 BC052890 CT010279
GenPept AAF19055 AAH46384 AAH52890 BAC27301 BAC33601 BAE30017 BAE30455 BAE31037 BAE31089 BAE31990 BAE33450 BAE35054 BAE36049 BAE39023 BAE41124 BAE41399 BAE42130 BAE42336 BAE42784 BAE43045 BAE43120 CAJ18487
RNA Seq Atlas 29876