InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clic4

Summary

InnateDB Gene

IDBG-196825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clic4

Gene Name

chloride intracellular channel 4 (mitochondrial)

Synonyms

D0Jmb3; mc3s5; mtCLIC; TU-74

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037242

Encoded Proteins

IDBP-196827

chloride intracellular channel 4 (mitochondrial)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169504:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:135213969-135272814

Strand

Reverse strand

Band

Transcripts

ENSMUST00000037099	ENSMUSP00000041453
ENSMUST00000143370

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001886	endothelial cell morphogenesis
GO:0006821	chloride transport
GO:0007035	vacuolar acidification
GO:0009566	fertilization
GO:0030216	keratinocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0034765	regulation of ion transmembrane transport
GO:0035264	multicellular organism growth
GO:0044070	regulation of anion transport
GO:0048754	branching morphogenesis of an epithelial tube
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0071277	cellular response to calcium ion
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0030659	cytoplasmic vesicle membrane
GO:0034707	chloride channel complex
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000169504

View Gene Order

ENSBTAG00000009470

Not yet available

Cross-References

SwissProt

Q9QYB1

TrEMBL

Q3U8I1 Q543N5

UniProt Splice Variant

Entrez Gene

29876

UniGene

Mm.257765 Mm.412244 Mm.473864

RefSeq

NM_013885

OMIM

CCDS

CCDS18783

HPRD

IMGT

MGI ID

MGI:1352754

MGI Symbol

Clic4

EMBL

AF102578 AK031211 AK049191 AK150993 AK151504 AK152209 AK152273 AK153432 AK155826 AK159402 AK160856 AK166794 AK169376 AK169834 AK170942 AK171243 AK172026 AK172516 AK172660 BC046384 BC052890 CT010279

GenPept

AAF19055 AAH46384 AAH52890 BAC27301 BAC33601 BAE30017 BAE30455 BAE31037 BAE31089 BAE31990 BAE33450 BAE35054 BAE36049 BAE39023 BAE41124 BAE41399 BAE42130 BAE42336 BAE42784 BAE43045 BAE43120 CAJ18487

RNA Seq Atlas

29876