Bos taurus Gene: CLIC4
InnateDB Gene IDBG-645329.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC4
Gene Name Chloride intracellular channel protein 4
Synonyms p64H1
Species Bos taurus
Ensembl Gene ENSBTAG00000009470
Encoded Proteins
Chloride intracellular channel protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169504:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:128710453-128783921
Strand Reverse strand
ENSBTAT00000054397 ENSBTAP00000048950
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007035 vacuolar acidification
GO:0009566 fertilization
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0034765 regulation of ion transmembrane transport
GO:0035264 multicellular organism growth
GO:0044070 regulation of anion transport
GO:0048754 branching morphogenesis of an epithelial tube
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0071277 cellular response to calcium ion
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0034707 chloride channel complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Homo sapiens
Mus musculus
Gene ID
Gene Order
SwissProt Q9XSA7
UniProt Splice Variant
Entrez Gene 286823
UniGene Bt.64763 Bt.75486
RefSeq NM_001080218
EMBL AF109198 BC103261
GenPept AAD26138 AAI03262
RNA Seq Atlas 286823