Homo sapiens Gene: FBLN2
Summary
InnateDB Gene IDBG-19758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBLN2
Gene Name fibulin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163520
Encoded Proteins
fibulin 2
fibulin 2
fibulin 2
fibulin 2
fibulin 2
fibulin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:13549131-13638422
Strand Forward strand
Band p25.1
Transcripts
ENST00000295761 ENSP00000295761
ENST00000295760 ENSP00000295760
ENST00000404922 ENSP00000384169
ENST00000421373 ENSP00000399224
ENST00000465610 ENSP00000420164
ENST00000492059 ENSP00000420042
ENST00000477845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P98095
TrEMBL C9JQS6 F5H1F3 Q9Y3V7
UniProt Splice Variant
Entrez Gene 2199
UniGene Hs.198862
RefSeq NM_001004019 NM_001165035 NM_001998
HUGO HGNC:3601
OMIM 135821
CCDS CCDS46761 CCDS46762
HPRD
IMGT
EMBL AC027124 AC090509 AK304827 AL050095 AY130456 AY130457 AY130458 AY130459 FJ695211 X82494
GenPept AAN05435 AAN05436 BAH14261 CAA57876 CAB43267
RNA Seq Atlas 2199