Mus musculus Gene: Bmf
Summary
InnateDB Gene IDBG-198160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmf
Gene Name BCL2 modifying factor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040093
Encoded Proteins
BCL2 modifying factor
BCL2 modifying factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104081:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:118528757-118549687
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000090219 ENSMUSP00000087686
ENSMUST00000110859 ENSMUSP00000106483
ENSMUST00000143583
ENSMUST00000154521
ENSMUST00000152123
ENSMUST00000125860
ENSMUST00000146962
ENSMUST00000138342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032464 positive regulation of protein homooligomerization
GO:0043276 anoikis
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptosis pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Activation of BH3-only proteins pathway
Activation of BMF and translocation to mitochondria pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Activation of BMF and translocation to mitochondria pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.210125
RefSeq NM_138313 XM_006498853 XM_006498854 XM_006498855 XM_006498856
OMIM
CCDS CCDS16578
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas