Bos taurus Gene: BMF
Summary
InnateDB Gene IDBG-646206.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMF
Gene Name bcl-2-modifying factor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012180
Encoded Proteins
bcl-2-modifying factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104081:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:35856697-35871287
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016157 ENSBTAP00000016157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0032464 positive regulation of protein homooligomerization
GO:0043276 anoikis
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Activation of BMF and translocation to mitochondria pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
Apoptosis pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Activation of BH3-only proteins pathway
Activation of BMF and translocation to mitochondria pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q05KI3
UniProt Splice Variant
Entrez Gene 541141
UniGene
RefSeq NM_001077485 XM_005211591 XM_005211592
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB238943 DAAA02028541
GenPept BAF35579
RNA Seq Atlas 541141
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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