Bos taurus Gene: BMF | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-646206.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | BMF | ||||||||||||
Gene Name | bcl-2-modifying factor | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000012180 | ||||||||||||
Encoded Proteins |
bcl-2-modifying factor
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104081:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 10:35856697-35871287 | ||||||||||||
Strand | Reverse strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH |
TCR pathway
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REACTOME |
Activation of BMF and translocation to mitochondria pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
Intrinsic Pathway for Apoptosis pathway
Apoptosis pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Activation of BH3-only proteins pathway
Activation of BMF and translocation to mitochondria pathway
Intrinsic Pathway for Apoptosis pathway
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KEGG | |||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | Q05KI3 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 541141 | ||||||||||||
UniGene | |||||||||||||
RefSeq | NM_001077485 XM_005211591 XM_005211592 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AB238943 DAAA02028541 | ||||||||||||
GenPept | BAF35579 | ||||||||||||
RNA Seq Atlas | 541141 | ||||||||||||