Mus musculus Gene: Gdf11
Summary
InnateDB Gene IDBG-198554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdf11
Gene Name growth differentiation factor 11
Synonyms BMP-11; Bmp11;
Species Mus musculus
Ensembl Gene ENSMUSG00000025352
Encoded Proteins
growth differentiation factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135414:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128882295-128891718
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026408 ENSMUSP00000026408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001501 skeletal system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0021512 spinal cord anterior/posterior patterning
GO:0031016 pancreas development
GO:0040007 growth
GO:0045596 negative regulation of cell differentiation
GO:0048469 cell maturation
GO:0048593 camera-type eye morphogenesis
GO:0060021 palate development
Cellular Component
GO:0005615 extracellular space
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
GPCR signaling pathway
BMP2 signaling pathway
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
GPCR signaling pathway
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Z1W4
TrEMBL
UniProt Splice Variant
Entrez Gene 14561
UniGene Mm.299218
RefSeq NM_010272
OMIM
CCDS CCDS24296
HPRD
IMGT
MGI ID MGI:1338027
MGI Symbol Gdf11
EMBL AF028335 AF028336 AF028337 AF092734 AF100904 AF100905 AF100906
GenPept AAC72853 AAD05267 AAF21633
RNA Seq Atlas 14561