Version 5.4
Mus musculus Gene: Asl
Summary
InnateDB Gene IDBG-202187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asl
Gene Name argininosuccinate lyase
Synonyms 2510006M18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000025533
Encoded Proteins
IDBP-542902
argininosuccinate lyase
IDBP-542907
argininosuccinate lyase
IDBP-542908
argininosuccinate lyase
IDBP-542909
argininosuccinate lyase
IDBP-542910
argininosuccinate lyase
IDBP-542911
argininosuccinate lyase
IDBP-542912
argininosuccinate lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126522:
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:130011258-130025132
Strand Reverse strand
Band G1.3
Transcripts
ENSMUST00000161094 ENSMUSP00000124274
ENSMUST00000160208 ENSMUSP00000125194
ENSMUST00000159619 ENSMUSP00000123799
ENSMUST00000160129 ENSMUSP00000124579
ENSMUST00000159096 ENSMUSP00000125143
ENSMUST00000161640 ENSMUSP00000124487
ENSMUST00000160557
ENSMUST00000161884 ENSMUSP00000123861
ENSMUST00000162230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity
Biological Process
GO:0000050 urea cycle
GO:0006475 internal protein amino acid acetylation
GO:0006520 cellular amino acid metabolic process
GO:0007626 locomotory behavior
GO:0009791 post-embryonic development
GO:0019676 ammonia assimilation cycle
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126522
View Gene Order
ENSBTAG00000015314
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_246679
Urea cycle pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00330
Arginine and proline metabolism pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_847
Urea cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
INOH website
Citrate cycle pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.23869 Mm.419412 Mm.461251 Mm.468143 Mm.480857
RefSeq NM_133768 XM_006504339 XM_006504340 XM_006504341
OMIM
CCDS CCDS51655
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca