Mus musculus Gene: Asl
Summary
InnateDB Gene IDBG-202187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asl
Gene Name argininosuccinate lyase
Synonyms 2510006M18Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000025533
Encoded Proteins
argininosuccinate lyase
argininosuccinate lyase
argininosuccinate lyase
argininosuccinate lyase
argininosuccinate lyase
argininosuccinate lyase
argininosuccinate lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126522:
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:130011258-130025132
Strand Reverse strand
Band G1.3
Transcripts
ENSMUST00000161094 ENSMUSP00000124274
ENSMUST00000160208 ENSMUSP00000125194
ENSMUST00000159619 ENSMUSP00000123799
ENSMUST00000160129 ENSMUSP00000124579
ENSMUST00000159096 ENSMUSP00000125143
ENSMUST00000161640 ENSMUSP00000124487
ENSMUST00000160557
ENSMUST00000161884 ENSMUSP00000123861
ENSMUST00000162230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity
Biological Process
GO:0000050 urea cycle
GO:0006475 internal protein amino acid acetylation
GO:0006520 cellular amino acid metabolic process
GO:0007626 locomotory behavior
GO:0009791 post-embryonic development
GO:0019676 ammonia assimilation cycle
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
Arginine Proline metabolism pathway
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q91YI0
TrEMBL E0CY49
UniProt Splice Variant
Entrez Gene 109900
UniGene Mm.23869 Mm.419412 Mm.461251 Mm.468143 Mm.480857
RefSeq XM_006504339 XM_006504340 XM_006504341 NM_133768
OMIM
CCDS CCDS51655
HPRD
IMGT
MGI ID MGI:88084
MGI Symbol Asl
EMBL AC161345 AK076453 AK140160 AK148764 AK168739 BC016670
GenPept AAH16670 BAC36348 BAE24262 BAE28659 BAE40580
RNA Seq Atlas 109900