InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ASL

Summary

InnateDB Gene

IDBG-639750.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASL

Gene Name

argininosuccinate lyase

Synonyms

ASAL

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015314

Encoded Proteins

IDBP-691947

argininosuccinate lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126522:
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:28247949-28256721

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020365

ENSBTAP00000020365

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004056	argininosuccinate lyase activity

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0007626	locomotory behavior
GO:0009791	post-embryonic development
GO:0019676	ammonia assimilation cycle
GO:0042450	arginine biosynthetic process via ornithine