Version 5.4
Homo sapiens Gene: HPX
Summary
InnateDB Gene IDBG-28944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPX
Gene Name hemopexin
Synonyms HX
Species Homo sapiens
Ensembl Gene ENSG00000110169
Encoded Proteins
IDBP-28946
hemopexin
IDBP-812044
hemopexin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6431049-6442617
Strand Reverse strand
Band p15.4
Transcripts
ENST00000265983 ENSP00000265983
ENST00000527556
ENST00000529037
ENST00000533561
ENST00000534429
ENST00000529775
ENST00000525057
ENST00000533369
ENST00000533856
ENST00000528348
ENST00000534800
ENST00000527105
ENST00000615166 ENSP00000479146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015232 heme transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006879 cellular iron ion homeostasis
GO:0015886 heme transport
GO:0016032 viral process
GO:0020027 hemoglobin metabolic process
GO:0042168 heme metabolic process
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0051246 regulation of protein metabolic process
GO:0060332 positive regulation of response to interferon-gamma
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0071682 endocytic vesicle lumen
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030895
View Gene Order
ENSBTAG00000003564
Not yet available
Pathways
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q9BS19
UniProt Splice Variant
Entrez Gene 3263
UniGene
RefSeq NM_000613 XM_005252883
HUGO HGNC:5171
OMIM 142290
CCDS CCDS7763
HPRD
IMGT
EMBL BC005395
GenPept AAH05395
RNA Seq Atlas 3263

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca