Homo sapiens Gene: POLR2B
Summary
InnateDB Gene IDBG-20530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2B
Gene Name polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Synonyms hRPB140; hsRPB2; POL2RB; RPB2;
Species Homo sapiens
Ensembl Gene ENSG00000047315
Encoded Proteins
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:56977722-57031168
Strand Forward strand
Band q12
Transcripts
ENST00000381227 ENSP00000370625
ENST00000314595 ENSP00000312735
ENST00000450656 ENSP00000408638
ENST00000431623 ENSP00000391096
ENST00000441246 ENSP00000391452
ENST00000433463 ENSP00000407728
ENST00000495311
ENST00000497845
ENST00000478188
ENST00000510355
ENST00000464918
ENST00000484821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 93 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0032549 ribonucleoside binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Formation of the Early Elongation Complex pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
MicroRNA (miRNA) biogenesis pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
mRNA Splicing - Minor Pathway pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Influenza Viral RNA Transcription and Replication pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
Tat-mediated HIV elongation arrest and recovery pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
Dual incision reaction in TC-NER pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
Transcription of the HIV genome pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
Influenza Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
mRNA Splicing pathway
HIV Transcription Initiation pathway
Formation of the HIV-1 Early Elongation Complex pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
DNA Repair pathway
mRNA Splicing - Major Pathway pathway
Regulatory RNA pathways pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B2WTN6 C9J4M6
UniProt Splice Variant
Entrez Gene 5431
UniGene Hs.602757
RefSeq NM_000938
HUGO HGNC:9188
OMIM 180661
CCDS CCDS3511
HPRD 15943
IMGT
EMBL AC069307 EF536006
GenPept ABX80206
RNA Seq Atlas 5431