Mus musculus Gene: Spna1
Summary
InnateDB Gene IDBG-206187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spna1
Gene Name spectrin alpha 1
Synonyms AF093576; AI451697; ha; ihj; nmf4; sph; Spna-1; Spna1;
Species Mus musculus
Ensembl Gene ENSMUSG00000026532
Encoded Proteins
spectrin alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163554:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:174172776-174248450
Strand Forward strand
Band H3
Transcripts
ENSMUST00000027817 ENSMUSP00000027817
ENSMUST00000156092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002260 lymphocyte homeostasis
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0007009 plasma membrane organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030097 hemopoiesis
GO:0032092 positive regulation of protein binding
GO:0042102 positive regulation of T cell proliferation
GO:0051693 actin filament capping
Cellular Component
GO:0008091 spectrin
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0032437 cuticular plate
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interaction between L1 and Ankyrins pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Interaction between L1 and Ankyrins pathway
NCAM signaling for neurite out-growth pathway
Axon guidance pathway
L1CAM interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P08032
TrEMBL
UniProt Splice Variant
Entrez Gene 20739
UniGene Mm.200611
RefSeq NM_011465
OMIM
CCDS CCDS35795
HPRD
IMGT
MGI ID MGI:98385
MGI Symbol Spta1
EMBL AC113483 AC156549 AF093576 BC150747 M10276 U87455
GenPept AAA40123 AAB47540 AAC61874 AAI50748
RNA Seq Atlas 20739