Bos taurus Gene: SPTA1
Summary
InnateDB Gene IDBG-630820.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPTA1
Gene Name spectrin alpha chain, erythrocyte
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000888
Encoded Proteins
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163554:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:11111861-11204434
Strand Forward strand
Band
Transcripts
ENSBTAT00000061417 ENSBTAP00000053194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002260 lymphocyte homeostasis
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0007009 plasma membrane organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030097 hemopoiesis
GO:0032092 positive regulation of protein binding
GO:0042102 positive regulation of T cell proliferation
Cellular Component
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0032437 cuticular plate
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Interaction between L1 and Ankyrins pathway
NCAM signaling for neurite out-growth pathway
Axon guidance pathway
L1CAM interactions pathway
Interaction between L1 and Ankyrins pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MMQ8
UniProt Splice Variant
Entrez Gene 790189
UniGene Bt.33206 Bt.89351
RefSeq NM_001206588 XM_001256728
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007018 DAAA02007019 DAAA02007020
GenPept
RNA Seq Atlas 505122 790189
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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