Version 5.4
Mus musculus Gene: Rbak
Summary
InnateDB Gene IDBG-207572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbak
Gene Name RB-associated KRAB repressor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000061898
Encoded Proteins
IDBP-207574
RB-associated KRAB repressor
IDBP-621383
RB-associated KRAB repressor
IDBP-621385
RB-associated KRAB repressor
IDBP-621386
RB-associated KRAB repressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146587:
This locus represents naturally occurring read-through transcription between the neighboring RBAK (RB-associated KRAB zinc finger) and LOC389458 (hypothetical LOC389458) genes on chromosome 7. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Mar 2011] This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:143172186-143180775
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000049861 ENSMUSP00000059273
ENSMUST00000165318 ENSMUSP00000128731
ENSMUST00000166382 ENSMUSP00000132239
ENSMUST00000164068 ENSMUSP00000133089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146587
View Gene Order
ENSBTAG00000010291
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q1P1
UniProt Splice Variant
Entrez Gene 57782
UniGene Mm.320419 Mm.401378
RefSeq NM_001045482 NM_021326 XM_006504723 XM_006504724
OMIM
CCDS CCDS19835
HPRD
IMGT
MGI ID MGI:1927369
MGI Symbol Rbak
EMBL AC123686
GenPept
RNA Seq Atlas 57782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca