Homo sapiens Gene: RBAK
Summary
InnateDB Gene IDBG-7390.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBAK
Gene Name RB-associated KRAB zinc finger
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146587
Encoded Proteins
RB-associated KRAB zinc finger
RB-associated KRAB zinc finger
RB-associated KRAB zinc finger
RB-associated KRAB zinc finger
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring RBAK (RB-associated KRAB zinc finger) and LOC389458 (hypothetical LOC389458) genes on chromosome 7. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Mar 2011] This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5045821-5069488
Strand Forward strand
Band p22.1
Transcripts
ENST00000353796 ENSP00000275423
ENST00000396912 ENSP00000380120
ENST00000396904 ENSP00000380112
ENST00000407184 ENSP00000385560
ENST00000476992
ENST00000498308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.396178 Hs.733005
RefSeq NM_001204513 NM_001204456 NM_021163
HUGO
OMIM
CCDS CCDS56463 CCDS5337
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas