Version 5.4
Mus musculus Gene: Il4ra
Summary
InnateDB Gene IDBG-209275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il4ra
Gene Name interleukin 4 receptor, alpha
Synonyms CD124; Il4r
Species Mus musculus
Ensembl Gene ENSMUSG00000030748
Encoded Proteins
IDBP-209277
interleukin 4 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21825018
The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis
InnateDB Annotation from Orthologs
Summary
PMID 8609418
[Homo sapiens] IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.
PMID 21825018
[Homo sapiens] The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077238:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:125552282-125579472
Strand Forward strand
Band F3
Transcripts
ENSMUST00000033004 ENSMUSP00000033004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 10 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0019221 cytokine-mediated signaling pathway
GO:0030728 ovulation
GO:0042127 regulation of cell proliferation
GO:0042832 defense response to protozoan
GO:0043032 positive regulation of macrophage activation
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077238
View Gene Order
ENSBTAG00000001602
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
INOH
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-13 signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
IL-4 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-13 signaling pathway
PID NCI
p73pathway
p73 transcription factor network
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P16382
TrEMBL A2VCP1 Q3U905 Q544A9 Q921I3 W8DL82
UniProt Splice Variant
Entrez Gene 16190
UniGene Mm.233802
RefSeq NM_001008700
OMIM
CCDS CCDS40121
HPRD
IMGT
MGI ID MGI:105367
MGI Symbol Il4ra
EMBL AF000304 AK034466 AK042342 AK088086 AK150584 AK151998 AK153186 AK159375 AK160016 BC012309 BC112911 BC128301 BC128302 CH466531 KC339001 M27959 M27960 M29854 M64870 M64871 M64872 M64873 M64874 M64876 M64877 M64878 M64879
GenPept AAA39297 AAA39299 AAA39300 AAB59727 AAB87750 AAH12309 AAI12912 AAI28302 AAI28303 AGZ84442 BAC28718 BAC31230 BAC40137 BAE29678 BAE30862 BAE31787 BAE35031 BAE35562 EDL17322 EDL17323
RNA Seq Atlas 16190

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca