Bos taurus Gene: IL4R
Summary
InnateDB Gene IDBG-638778.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL4R
Gene Name interleukin-4 receptor subunit alpha precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001602
Encoded Proteins
interleukin-4 receptor subunit alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.
[Homo sapiens] The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)
[Mus musculus] The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077238:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:25139417-25189373
Strand Forward strand
Band
Transcripts
ENSBTAT00000002098 ENSBTAP00000002098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0019221 cytokine-mediated signaling pathway
GO:0042832 defense response to protozoan
GO:0043032 positive regulation of macrophage activation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
IL4 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
PID BIOCARTA
Il 4 signaling pathway [Biocarta view]
PID NCI
p73 transcription factor network
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL Q148M2
UniProt Splice Variant
Entrez Gene 404154
UniGene Bt.45933
RefSeq NM_001075142
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118151 DAAA02057867
GenPept AAI18152
RNA Seq Atlas 404154
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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