InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL4R

Summary

InnateDB Gene

IDBG-638778.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4R

Gene Name

interleukin-4 receptor subunit alpha precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001602

Encoded Proteins

IDBP-690880

interleukin-4 receptor subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 8609418

[Homo sapiens] IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.

PMID 21825018

[Homo sapiens] The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)

PMID 21825018

[Mus musculus] The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077238:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:25139417-25189373

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002098

ENSBTAP00000002098

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0002532	production of molecular mediator involved in inflammatory response
GO:0019221	cytokine-mediated signaling pathway
GO:0042832	defense response to protozoan
GO:0043032	positive regulation of macrophage activation
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0090197	positive regulation of chemokine secretion