Version 5.4
Mus musculus Gene: Aldoa
Summary
InnateDB Gene IDBG-209847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldoa
Gene Name aldolase A, fructose-bisphosphate
Synonyms Aldo-1; Aldo1
Species Mus musculus
Ensembl Gene ENSMUSG00000030695
Encoded Proteins
IDBP-170254
aldolase A, fructose-bisphosphate
IDBP-209849
aldolase A, fructose-bisphosphate
IDBP-268949
aldolase A, fructose-bisphosphate
IDBP-535594
aldolase A, fructose-bisphosphate
IDBP-541149
aldolase A, fructose-bisphosphate
IDBP-539832
aldolase A, fructose-bisphosphate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149925:
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126795234-126800751
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000087566 ENSMUSP00000084846
ENSMUST00000032934 ENSMUSP00000032934
ENSMUST00000106348 ENSMUSP00000101955
ENSMUST00000135707
ENSMUST00000139657
ENSMUST00000143509
ENSMUST00000151137 ENSMUSP00000118417
ENSMUST00000147748
ENSMUST00000133514 ENSMUSP00000114587
ENSMUST00000141355 ENSMUSP00000117349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004332 fructose-bisphosphate aldolase activity
Biological Process
GO:0001666 response to hypoxia
GO:0006096 glycolytic process
GO:0009408 response to heat
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0043627 response to estrogen
GO:0051289 protein homotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0030018 Z disc
GO:0031430 M band
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149925
View Gene Order
ENSBTAG00000012927
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_232322
Glycolysis pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263230
Gluconeogenesis pathway
REACT_203949
Glycogen storage diseases pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00030
Pentose phosphate pathway pathway
mmu00051
Fructose and mannose metabolism pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_1383
Glycolysis pathway
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00030
Pentose phosphate pathway pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Fructose Mannose metabolism pathway
INOH website
Pentose phosphate cycle pathway
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.488432
RefSeq NM_001177307 NM_001177308 NM_007438 XM_006507209 XM_006507210 XM_006507211
OMIM
CCDS CCDS21845 CCDS52399
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca