Mus musculus Gene: Aldoa
Summary
InnateDB Gene IDBG-209847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldoa
Gene Name aldolase A, fructose-bisphosphate
Synonyms Aldo-1; Aldo1;
Species Mus musculus
Ensembl Gene ENSMUSG00000030695
Encoded Proteins
aldolase A, fructose-bisphosphate
aldolase A, fructose-bisphosphate
aldolase A, fructose-bisphosphate
aldolase A, fructose-bisphosphate
aldolase A, fructose-bisphosphate
aldolase A, fructose-bisphosphate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149925:
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126795234-126800751
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000087566 ENSMUSP00000084846
ENSMUST00000032934 ENSMUSP00000032934
ENSMUST00000106348 ENSMUSP00000101955
ENSMUST00000135707
ENSMUST00000139657
ENSMUST00000143509
ENSMUST00000151137 ENSMUSP00000118417
ENSMUST00000147748
ENSMUST00000133514 ENSMUSP00000114587
ENSMUST00000141355 ENSMUSP00000117349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004332 fructose-bisphosphate aldolase activity
Biological Process
GO:0001666 response to hypoxia
GO:0006096 glycolytic process
GO:0009408 response to heat
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0043627 response to estrogen
GO:0051289 protein homotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0030018 Z disc
GO:0031430 M band
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Disease pathway
Hemostasis pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Platelet activation, signaling and aggregation pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Response to elevated platelet cytosolic Ca2+ pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Gluconeogenesis pathway
Response to elevated platelet cytosolic Ca2+ pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
INOH
Fructose Mannose metabolism pathway
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL D3Z510
UniProt Splice Variant
Entrez Gene 11674
UniGene Mm.488432
RefSeq NM_001177307 NM_001177308 NM_007438 XM_006507209 XM_006507210 XM_006507211
OMIM
CCDS CCDS21845 CCDS52399
HPRD
IMGT
MGI ID MGI:87994
MGI Symbol Aldoa
EMBL AC124505
GenPept
RNA Seq Atlas 11674