Mus musculus Gene: Tbx21
Summary
InnateDB Gene IDBG-210153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx21
Gene Name T-box 21
Synonyms Tbet; Tblym; TBT1;
Species Mus musculus
Ensembl Gene ENSMUSG00000001444
Encoded Proteins
T-box 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.
Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.
Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073861:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:97098071-97115331
Strand Reverse strand
Band D
Transcripts
ENSMUST00000001484 ENSMUSP00000001484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 27 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009615 response to virus
GO:0030217 T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0071310 cellular response to organic substance
GO:0072676 lymphocyte migration
Cellular Component
GO:0005634 nucleus
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
Cross-References
SwissProt Q9JKD8
TrEMBL Q3U150 Q5PSB0
UniProt Splice Variant
Entrez Gene 57765
UniGene Mm.490611 Mm.94519
RefSeq NM_019507
OMIM
CCDS CCDS25315
HPRD
IMGT
MGI ID MGI:1888984
MGI Symbol Tbx21
EMBL AF093099 AF241242 AK156271 AY836551 BC137986 BC137988 CH466556
GenPept AAF00056 AAF61242 AAI37987 AAI37989 AAV83787 BAE33650 EDL16071
RNA Seq Atlas 57765