InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tbx21

Summary

InnateDB Gene

IDBG-210153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbx21

Gene Name

T-box 21

Synonyms

Tbet; Tblym; TBT1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001444

Encoded Proteins

IDBP-210155

T-box 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 11752460

Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.

PMID 23063332

Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.

PMID 23334414

Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073861:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:97098071-97115331

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001484

ENSMUSP00000001484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	27 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009615	response to virus
GO:0030217	T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0071310	cellular response to organic substance
GO:0072676	lymphocyte migration

Cellular Component

GO:0005634	nucleus
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000073861

View Gene Order

ENSBTAG00000014199

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

il27pathway

IL27-mediated signaling events

il12_2pathway

IL12-mediated signaling events

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

il12_stat4pathway

IL12 signaling mediated by STAT4

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

Q9JKD8

TrEMBL

Q3U150 Q5PSB0

UniProt Splice Variant

Entrez Gene

57765

UniGene

Mm.490611 Mm.94519

RefSeq

NM_019507

OMIM

CCDS

CCDS25315

HPRD

IMGT

MGI ID

MGI:1888984

MGI Symbol

Tbx21

EMBL

AF093099 AF241242 AK156271 AY836551 BC137986 BC137988 CH466556

GenPept

AAF00056 AAF61242 AAI37987 AAI37989 AAV83787 BAE33650 EDL16071

RNA Seq Atlas

57765