|Mus musculus Gene: Tbx21|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||T-box 21|
|Synonyms||Tbet; Tblym; TBT1;|
|Useful resources||Stemformatics EHFPI ImmGen|
Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.
Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.
Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073861:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 11:97098071-97115331|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
|UniProt Splice Variant|
|EMBL||AF093099 AF241242 AK156271 AY836551 BC137986 BC137988 CH466556|
|GenPept||AAF00056 AAF61242 AAI37987 AAI37989 AAV83787 BAE33650 EDL16071|
|RNA Seq Atlas||57765|