Bos taurus Gene: TBX21
Summary
InnateDB Gene IDBG-639079.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX21
Gene Name T-box transcription factor TBX21
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014199
Encoded Proteins
T-box 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tbx21 (T-bet) is a member of the T-box transcription factor family that plays a critical role in interferon (IFN)-gamma regulation and promotion of cell-mediated immune responses against intracellular pathogens.
[Mus musculus] Tbx21 (T-bet) regulates the interplay between mucosal dendritic cells, innate lymphoid cells, and the intestinal microbiota.
[Mus musculus] Gradual expression of Tbx21 controls the fate and function of innate lymphoid cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073861:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39351741-39363523
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018875 ENSBTAP00000018875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009615 response to virus
GO:0030217 T cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0071310 cellular response to organic substance
GO:0072676 lymphocyte migration
Cellular Component
GO:0005634 nucleus
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.44725
RefSeq NM_001192140
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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