Homo sapiens Gene: CLIP2
Summary
InnateDB Gene IDBG-21163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIP2
Gene Name CAP-GLY domain containing linker protein 2
Synonyms CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4; WSCR3; WSCR4;
Species Homo sapiens
Ensembl Gene ENSG00000106665
Encoded Proteins
CAP-GLY domain containing linker protein 2
CAP-GLY domain containing linker protein 2
CAP-GLY domain containing linker protein 2
CAP-GLY domain containing linker protein 2
CAP-GLY domain containing linker protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:74289475-74405943
Strand Forward strand
Band q11.23
Transcripts
ENST00000223398 ENSP00000223398
ENST00000361545 ENSP00000355151
ENST00000395060 ENSP00000378500
ENST00000487091
ENST00000493166 ENSP00000417597
ENST00000482424
ENST00000491075
ENST00000474962
ENST00000487447 ENSP00000419938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051010 microtubule plus-end binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005875 microtubule associated complex
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane
GO:0035371 microtubule plus-end
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9UDT6
TrEMBL Q7Z5B7
UniProt Splice Variant
Entrez Gene 7461
UniGene Hs.647018
RefSeq NM_003388 NM_032421
HUGO HGNC:2586
OMIM 603432
CCDS CCDS5569 CCDS5570
HPRD
IMGT
EMBL AB006629 AC005015 AF041055 AF041056 AF041057 AF041058 AF041059 AY295764
GenPept AAB96784 AAF03524 AAP91873 BAA22960
RNA Seq Atlas 7461