Homo sapiens Gene: SIGIRR
Summary
InnateDB Gene IDBG-16551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGIRR
Gene Name single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185187
Encoded Proteins
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SIGIRR is a negative modulator of TLR-IL-1R signalling where it binds to the TLR-IL-1R signalling components in a ligand-dependent way.
SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signalling pathway.
SIGIRR regulates innate responses in differentiated human intestinal epithelial cells (IECs), modulating epithelial involvement in infectious and inflammatory bowel diseases.
SIGIRR can inhibit Toll-like receptor (TLR) 4, 5, and 9-mediated immune responses by attenuating production of the inflammatory mediators IL-6 and TNF-alpha and this attenuation was not the result of decreased expression of TLR4, 5 or 9, but rather a sequestration of MYD88 to the TLRs.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:405716-417455
Strand Reverse strand
Band p15.5
Transcripts
ENST00000332725 ENSP00000333656
ENST00000397632 ENSP00000380756
ENST00000431843 ENSP00000403104
ENST00000528845 ENSP00000434164
ENST00000526395 ENSP00000433530
ENST00000527295
ENST00000527987
ENST00000531205 ENSP00000433022
ENST00000534145
ENST00000528209 ENSP00000435135
ENST00000525299
ENST00000528698
ENST00000534217
ENST00000528536
ENST00000526788
ENST00000530494 ENSP00000434030
ENST00000529486
ENST00000530683
ENST00000528116
ENST00000527136
ENST00000528058 ENSP00000431698
ENST00000525070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501624
RefSeq NM_001135053 NM_001135054 NM_021805 XM_005253044 XM_005253045 XM_005253046
HUGO
OMIM
CCDS CCDS31325
HPRD 12018
IMGT
EMBL
GenPept
RNA Seq Atlas