Version 5.4
Homo sapiens Gene: SIGIRR
Summary
InnateDB Gene IDBG-16551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGIRR
Gene Name single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185187
Encoded Proteins
IDBP-16553
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-234933
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-360624
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-587407
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-587140
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-600580
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-584253
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-594678
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
IDBP-589167
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 12925853
SIGIRR is a negative modulator of TLR-IL-1R signalling where it binds to the TLR-IL-1R signalling components in a ligand-dependent way.
PMID 20060329
SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signalling pathway.
PMID 20130217
SIGIRR regulates innate responses in differentiated human intestinal epithelial cells (IECs), modulating epithelial involvement in infectious and inflammatory bowel diseases.
PMID 20364327
SIGIRR can inhibit Toll-like receptor (TLR) 4, 5, and 9-mediated immune responses by attenuating production of the inflammatory mediators IL-6 and TNF-alpha and this attenuation was not the result of decreased expression of TLR4, 5 or 9, but rather a sequestration of MYD88 to the TLRs.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:405716-417455
Strand Reverse strand
Band p15.5
Transcripts
ENST00000332725 ENSP00000333656
ENST00000397632 ENSP00000380756
ENST00000431843 ENSP00000403104
ENST00000528845 ENSP00000434164
ENST00000526395 ENSP00000433530
ENST00000527295
ENST00000527987
ENST00000531205 ENSP00000433022
ENST00000534145
ENST00000528209 ENSP00000435135
ENST00000525299
ENST00000528698
ENST00000534217
ENST00000528536
ENST00000526788
ENST00000530494 ENSP00000434030
ENST00000529486
ENST00000530683
ENST00000528116
ENST00000527136
ENST00000528058 ENSP00000431698
ENST00000525070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025494
View Gene Order
ENSBTAG00000011149
Not yet available
Pathways
NETPATH
REACTOME
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501624
RefSeq NM_001135053 NM_001135054 NM_021805 XM_005253044 XM_005253045 XM_005253046
HUGO
OMIM
CCDS CCDS31325
HPRD 12018
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca