Mus musculus Gene: Grn
Summary
InnateDB Gene IDBG-212642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grn
Gene Name granulin
Synonyms epithelin; Pgrn;
Species Mus musculus
Ensembl Gene ENSMUSG00000034708
Encoded Proteins
granulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030582:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102430315-102437048
Strand Forward strand
Band D
Transcripts
ENSMUST00000049460 ENSMUSP00000046340
ENSMUST00000127530
ENSMUST00000129997 ENSMUSP00000135739
ENSMUST00000135517
ENSMUST00000148580
ENSMUST00000123500
ENSMUST00000138451
ENSMUST00000125819 ENSMUSP00000134948
ENSMUST00000176953
ENSMUST00000177428 ENSMUSP00000134893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001835 blastocyst hatching
GO:0007566 embryo implantation
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1568
RefSeq NM_008175
OMIM
CCDS CCDS48943
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas