|Mus musculus Gene: Grn|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Useful resources||Stemformatics EHFPI ImmGen|
Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.
|InnateDB Annotation from Orthologs|
[Homo sapiens] GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030582:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 11:102430315-102437048|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas|