InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grn

Summary

InnateDB Gene

IDBG-212642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grn

Gene Name

granulin

Synonyms

epithelin; Pgrn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034708

Encoded Proteins

IDBP-212644

granulin

IDBP-717388

IDBP-718468

IDBP-716910

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21497117

Grn is an essential secreted cofactor that potentiates Tlr9-driven response to CpG olignonucletides by binding directly to CpG oligos and Tlr9. Grn deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG.

InnateDB Annotation from Orthologs

Summary

PMID 21497117

[Homo sapiens] GRN is an essential secreted cofactor that potentiates TLR9-driven response to CpG olignonucletides by binding directly to CpG oligos and TLR9. GRN deficient murine macrophages showed impaired delivery of CpG oligos to endolysosomal compartments and reduced response to CpG. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030582:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102430315-102437048

Strand

Forward strand

Band

Transcripts

ENSMUST00000049460	ENSMUSP00000046340
ENSMUST00000127530
ENSMUST00000129997	ENSMUSP00000135739
ENSMUST00000135517
ENSMUST00000148580
ENSMUST00000123500
ENSMUST00000138451
ENSMUST00000125819	ENSMUSP00000134948
ENSMUST00000176953
ENSMUST00000177428	ENSMUSP00000134893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001835	blastocyst hatching
GO:0007566	embryo implantation
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000030582

View Gene Order

ENSBTAG00000018823

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1568

RefSeq

NM_008175

OMIM

CCDS

CCDS48943

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas