Version 5.4
| Mus musculus Gene: Fgf3 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-212945.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Fgf3 | ||||||||||||||||||||||
| Gene Name | fibroblast growth factor 3 | ||||||||||||||||||||||
| Synonyms | Fgf-3; Int-2; Int-P | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000031074 | ||||||||||||||||||||||
| Encoded Proteins |
fibroblast growth factor 3
fibroblast growth factor 3
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186895:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 7:144838083-144844436 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | F5 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME | |||||||||||||||||||||||
| KEGG |
Melanoma pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Pathways in cancer pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Negative regulation of FGFR signaling pathway
Phospholipase C-mediated cascade pathway
SHC-mediated cascade pathway
PI-3K cascade pathway
FRS2-mediated cascade pathway
FGFR2b ligand binding and activation pathway
FGFR1b ligand binding and activation pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activated point mutants of FGFR2 pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR1 ligand binding and activation pathway
Disease pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Melanoma pathway
Pathways in cancer pathway
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| INOH |
FGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | D3YWD4 Q0VG15 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 14174 | ||||||||||||||||||||||
| UniGene | Mm.4947 | ||||||||||||||||||||||
| RefSeq | NM_008007 XM_006508484 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS22051 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:95517 | ||||||||||||||||||||||
| MGI Symbol | Fgf3 | ||||||||||||||||||||||
| EMBL | AC149593 BC117059 BC117061 CH466531 | ||||||||||||||||||||||
| GenPept | AAI17060 AAI17062 EDL18269 EDL18270 | ||||||||||||||||||||||
| RNA Seq Atlas | 14174 | ||||||||||||||||||||||