InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Strada

Summary

InnateDB Gene

IDBG-213381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Strada

Gene Name

STE20-related kinase adaptor alpha

Synonyms

2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000069631

Encoded Proteins

IDBP-213383

STE20-related kinase adaptor alpha

IDBP-213389

STE20-related kinase adaptor alpha

IDBP-267865

STE20-related kinase adaptor alpha

IDBP-531934

STE20-related kinase adaptor alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000266173:
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106163330-106202168

Strand

Reverse strand

Band

Transcripts

ENSMUST00000007444	ENSMUSP00000007444
ENSMUST00000103072	ENSMUSP00000099361
ENSMUST00000106867	ENSMUSP00000102480
ENSMUST00000122989
ENSMUST00000152008	ENSMUSP00000115555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019900	kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007049	cell cycle
GO:0032147	activation of protein kinase activity
GO:0035556	intracellular signal transduction