Version 5.4
Homo sapiens Gene: STRADA
Summary
InnateDB Gene IDBG-727185.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STRADA
Gene Name STE20-related kinase adaptor alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000266173
Encoded Proteins
IDBP-63525
STE20-related kinase adaptor alpha
IDBP-63529
STE20-related kinase adaptor alpha
IDBP-63531
STE20-related kinase adaptor alpha
IDBP-244612
STE20-related kinase adaptor alpha
IDBP-382975
STE20-related kinase adaptor alpha
IDBP-757853
IDBP-761086
IDBP-758396
IDBP-758921
IDBP-760029
IDBP-759444
IDBP-758706
IDBP-757892
IDBP-759807
IDBP-760433
IDBP-760969
IDBP-807342
STE20-related kinase adaptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63702832-63741970
Strand Reverse strand
Band q23.3
Transcripts
ENST00000336174 ENSP00000336655
ENST00000375840 ENSP00000365000
ENST00000245865 ENSP00000245865
ENST00000392950 ENSP00000376677
ENST00000447001 ENSP00000398841
ENST00000581243 ENSP00000464085
ENST00000582026 ENSP00000464213
ENST00000578008 ENSP00000464547
ENST00000580288 ENSP00000463238
ENST00000577375
ENST00000580039
ENST00000583085
ENST00000578801 ENSP00000463872
ENST00000582137 ENSP00000462922
ENST00000580338 ENSP00000463203
ENST00000579549 ENSP00000462384
ENST00000582030 ENSP00000464139
ENST00000579350
ENST00000578507
ENST00000579340 ENSP00000462530
ENST00000584110 ENSP00000462496
ENST00000579318
ENST00000581505
ENST00000617949 ENSP00000481505
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019900 kinase binding
GO:0030295 protein kinase activator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0007050 cell cycle arrest
GO:0008286 insulin receptor signaling pathway
GO:0032147 activation of protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069631
View Gene Order
ENSBTAG00000000056
Not yet available
Pathways
NETPATH
REACTOME
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_456
PKB-mediated events pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
KEGG
hsa04150
mTOR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514402 Hs.614065
RefSeq NM_001003786 NM_001003787 NM_001003788 NM_001165969 NM_001165970 NM_153335 XM_005257797 XM_005257798 XM_005257799
HUGO
OMIM
CCDS CCDS11642 CCDS32703 CCDS42367 CCDS54156 CCDS58585
HPRD 14332
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca