Homo sapiens Gene: NCF1
Summary
InnateDB Gene IDBG-21570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCF1
Gene Name neutrophil cytosolic factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158517
Encoded Proteins
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:74773962-74789315
Strand Forward strand
Band q11.23
Transcripts
ENST00000289473 ENSP00000289473
ENST00000398421
ENST00000449343
ENST00000433458 ENSP00000392870
ENST00000438106
ENST00000455062
ENST00000442021 ENSP00000401935
ENST00000443956
ENST00000464878 ENSP00000484502
ENST00000488197
ENST00000486097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 67 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0017124 SH3 domain binding
GO:0035091 phosphatidylinositol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001878 response to yeast
GO:0001909 leukocyte mediated cytotoxicity
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002679 respiratory burst involved in defense response
GO:0006612 protein targeting to membrane
GO:0006691 leukotriene metabolic process
GO:0006801 superoxide metabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0008283 cell proliferation
GO:0009617 response to bacterium
GO:0042554 superoxide anion generation
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0045730 respiratory burst
GO:0045986 negative regulation of smooth muscle contraction
GO:0050665 hydrogen peroxide biosynthetic process
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0051701 interaction with host
GO:0055114 oxidation-reduction process
GO:0070946 neutrophil mediated killing of gram-positive bacterium
GO:0070947 neutrophil mediated killing of fungus
GO:0090382 phagosome maturation
Cellular Component
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0030425 dendrite
GO:0032010 phagolysosome
GO:0043020 NADPH oxidase complex
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Signaling by VEGF pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Phagosomal maturation (early endosomal stage) pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Chemokine signaling pathway pathway
Phagosome pathway
Osteoclast differentiation pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
INOH
PID BIOCARTA
PID NCI
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 653361
UniGene Hs.647047
RefSeq NM_000265
HUGO HGNC:7660
OMIM 608512
CCDS CCDS34657
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 653361