InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCF1

Summary

InnateDB Gene

IDBG-21570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCF1

Gene Name

neutrophil cytosolic factor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000158517

Encoded Proteins

IDBP-21572

neutrophil cytosolic factor 1

IDBP-379077

neutrophil cytosolic factor 1

IDBP-379095

neutrophil cytosolic factor 1

IDBP-812392

neutrophil cytosolic factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:74773962-74789315

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000289473	ENSP00000289473
ENST00000398421
ENST00000449343
ENST00000433458	ENSP00000392870
ENST00000438106
ENST00000455062
ENST00000442021	ENSP00000401935
ENST00000443956
ENST00000464878	ENSP00000484502
ENST00000488197
ENST00000486097

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0035091	phosphatidylinositol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001878	response to yeast
GO:0001909	leukocyte mediated cytotoxicity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002679	respiratory burst involved in defense response
GO:0006612	protein targeting to membrane
GO:0006691	leukotriene metabolic process
GO:0006801	superoxide metabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0008283	cell proliferation
GO:0009617	response to bacterium
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0045986	negative regulation of smooth muscle contraction
GO:0050665	hydrogen peroxide biosynthetic process
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0070946	neutrophil mediated killing of gram-positive bacterium
GO:0070947	neutrophil mediated killing of fungus
GO:0090382	phagosome maturation

Cellular Component

GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019898	extrinsic component of membrane
GO:0030425	dendrite
GO:0032010	phagolysosome
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body