Homo sapiens Gene: MEP1B
Summary
InnateDB Gene IDBG-2209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEP1B
Gene Name meprin A, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141434
Encoded Proteins
meprin A, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:32185069-32220404
Strand Forward strand
Band q12.1
Transcripts
ENST00000269202 ENSP00000269202
ENST00000581447 ENSP00000463280
ENST00000579919
ENST00000581184 ENSP00000462038
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0007586 digestion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL J3KRK1
UniProt Splice Variant
Entrez Gene 4225
UniGene Hs.194777
RefSeq NM_005925 XM_005258275
HUGO HGNC:7020
OMIM 600389
CCDS CCDS45846
HPRD 02667
IMGT
EMBL AC011825 AC015563
GenPept
RNA Seq Atlas 4225