Version 5.4
Homo sapiens Gene: PDE4D
Summary
InnateDB Gene IDBG-22659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4D
Gene Name phosphodiesterase 4D, cAMP-specific
Synonyms ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4DN2; STRK1
Species Homo sapiens
Ensembl Gene ENSG00000113448
Encoded Proteins
IDBP-22661
phosphodiesterase 4D, cAMP-specific
IDBP-22663
phosphodiesterase 4D, cAMP-specific
IDBP-22665
phosphodiesterase 4D, cAMP-specific
IDBP-22669
phosphodiesterase 4D, cAMP-specific
IDBP-27309
phosphodiesterase 4D, cAMP-specific
IDBP-294781
phosphodiesterase 4D, cAMP-specific
IDBP-478054
phosphodiesterase 4D, cAMP-specific
IDBP-479763
phosphodiesterase 4D, cAMP-specific
IDBP-476621
phosphodiesterase 4D, cAMP-specific
IDBP-480959
phosphodiesterase 4D, cAMP-specific
IDBP-484079
phosphodiesterase 4D, cAMP-specific
IDBP-476008
phosphodiesterase 4D, cAMP-specific
IDBP-483128
phosphodiesterase 4D, cAMP-specific
IDBP-477806
phosphodiesterase 4D, cAMP-specific
IDBP-473567
phosphodiesterase 4D, cAMP-specific
IDBP-602882
phosphodiesterase 4D, cAMP-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
This gene encodes one of four mammalian counterparts to the fruit fly \'dunce\' gene. The encoded protein has 3\',5\'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:58969038-60522120
Strand Reverse strand
Band q12.1
Transcripts
ENST00000358923 ENSP00000351800
ENST00000360047 ENSP00000353152
ENST00000317118 ENSP00000321739
ENST00000340635 ENSP00000345502
ENST00000309641 ENSP00000308485
ENST00000405755 ENSP00000384806
ENST00000405053
ENST00000507116 ENSP00000424852
ENST00000503258 ENSP00000425605
ENST00000515011
ENST00000502484 ENSP00000423094
ENST00000505453 ENSP00000421013
ENST00000502575 ENSP00000425917
ENST00000515324
ENST00000514231
ENST00000512069
ENST00000509368 ENSP00000423555
ENST00000509355
ENST00000504624
ENST00000506024
ENST00000506510
ENST00000511382
ENST00000505507 ENSP00000425910
ENST00000514552 ENSP00000421829
ENST00000515835 ENSP00000424281
ENST00000546160 ENSP00000442734
ENST00000621323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002027 regulation of heart rate
GO:0006198 cAMP catabolic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007568 aging
GO:0007613 memory
GO:0008152 metabolic process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 regulation of receptor activity
GO:0010738 regulation of protein kinase A signaling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 positive regulation of smooth muscle cell migration
GO:0019933 cAMP-mediated signaling
GO:0030324 lung development
GO:0030593 neutrophil chemotaxis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035264 multicellular organism growth
GO:0043623 cellular protein complex assembly
GO:0045822 negative regulation of heart contraction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071222 cellular response to lipopolysaccharide
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle
Cellular Component
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030016 myofibril
GO:0034704 calcium channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021699
View Gene Order
ENSBTAG00000000494
Not yet available
Pathways
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.117545 Hs.605986 Hs.618643 Hs.641746 Hs.669817 Hs.706461 Hs.734623
RefSeq NM_001104631 NM_001165899 NM_001197218 NM_001197219 NM_001197220 NM_001197221 NM_001197222 NM_001197223 NM_006203 XM_005248537 XM_005248538 XM_005248540 XM_005248541
HUGO
OMIM
CCDS CCDS47213 CCDS54858 CCDS54859 CCDS56369 CCDS56370 CCDS56371 CCDS56372 CCDS56373
HPRD 02530
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca