InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SULT1A1

Summary

InnateDB Gene

IDBG-22979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A1

Gene Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

Synonyms

HAST1/HAST2; P-PST; PST; ST1A1; ST1A3; STP; STP1; TSPST1

Species

Homo sapiens

Ensembl Gene

ENSG00000196502

Encoded Proteins

IDBP-22981

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

IDBP-22983

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

IDBP-239192

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

IDBP-239194

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

IDBP-751952

IDBP-745960

IDBP-748126

IDBP-746790

IDBP-751783

IDBP-751584

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:28605196-28623625

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000350842	ENSP00000329399
ENST00000314752	ENSP00000321988
ENST00000395609	ENSP00000378972
ENST00000395607	ENSP00000378971
ENST00000563493	ENSP00000457083
ENST00000569554	ENSP00000457912
ENST00000567998
ENST00000562058	ENSP00000456215
ENST00000567512	ENSP00000455979
ENST00000566189	ENSP00000456459
ENST00000564818	ENSP00000454388

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047894	flavonol 3-sulfotransferase activity
GO:0050294	steroid sulfotransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0008210	estrogen metabolic process
GO:0009308	amine metabolic process
GO:0009812	flavonoid metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation

Cellular Component

GO:0005829	cytosol
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030711

View Gene Order

ENSBTAG00000008635

Not yet available

Pathways

NETPATH

REACTOME

REACT_6913

Cytosolic sulfonation of small molecules pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.567342 Hs.716834 Hs.736805

RefSeq

NM_001055 NM_177529 NM_177530 NM_177534 NM_177536 XM_005255522 XM_006721078

HUGO

OMIM

CCDS

CCDS10637 CCDS32420

HPRD

01372

IMGT

EMBL

GenPept

RNA Seq Atlas