Homo sapiens Gene: SULT1A1
Summary
InnateDB Gene IDBG-22979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULT1A1
Gene Name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Synonyms HAST1/HAST2; P-PST; PST; ST1A1; ST1A3; STP; STP1; TSPST1;
Species Homo sapiens
Ensembl Gene ENSG00000196502
Encoded Proteins
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28605196-28623625
Strand Reverse strand
Band p11.2
Transcripts
ENST00000350842 ENSP00000329399
ENST00000314752 ENSP00000321988
ENST00000395609 ENSP00000378972
ENST00000395607 ENSP00000378971
ENST00000563493 ENSP00000457083
ENST00000569554 ENSP00000457912
ENST00000567998
ENST00000562058 ENSP00000456215
ENST00000567512 ENSP00000455979
ENST00000566189 ENSP00000456459
ENST00000564818 ENSP00000454388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0047894 flavonol 3-sulfotransferase activity
GO:0050294 steroid sulfotransferase activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008210 estrogen metabolic process
GO:0009308 amine metabolic process
GO:0009812 flavonoid metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005829 cytosol
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Phase II conjugation pathway
Metabolism pathway
Cytosolic sulfonation of small molecules pathway
Biological oxidations pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BRY5
UniProt Splice Variant
Entrez Gene 6817
UniGene Hs.567342 Hs.716834 Hs.736805
RefSeq NM_001055 NM_177529 NM_177530 NM_177534 NM_177536 XM_005255522 XM_006721078
HUGO HGNC:11453
OMIM 171150
CCDS CCDS10637 CCDS32420
HPRD 01372
IMGT
EMBL AC020765
GenPept
RNA Seq Atlas 6817