Homo sapiens Gene: LDHB
Summary
InnateDB Gene IDBG-23010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDHB
Gene Name lactate dehydrogenase B
Synonyms HEL-S-281; LDH-B; LDH-H; LDHBD; TRG-5;
Species Homo sapiens
Ensembl Gene ENSG00000111716
Encoded Proteins
lactate dehydrogenase B
lactate dehydrogenase B
lactate dehydrogenase B
lactate dehydrogenase B
lactate dehydrogenase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21635342-21757857
Strand Reverse strand
Band p12.1
Transcripts
ENST00000350669 ENSP00000229319
ENST00000396076 ENSP00000379386
ENST00000396075 ENSP00000379385
ENST00000450584 ENSP00000398015
ENST00000470985
ENST00000470280
ENST00000542765
ENST00000539782 ENSP00000442680
ENST00000544151
ENST00000535112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 69 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004457 lactate dehydrogenase activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0019674 NAD metabolic process
GO:0044237 cellular metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Disease pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
INOH
Methionine Cysteine metabolism pathway
Propanoate metabolism pathway
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J7H8 F5H793
UniProt Splice Variant
Entrez Gene 3945
UniGene
RefSeq NM_001174097 NM_002300
HUGO HGNC:6541
OMIM 150100
CCDS CCDS8691
HPRD 01026
IMGT
EMBL AC010185 AC010197
GenPept
RNA Seq Atlas 3945