Bos taurus Gene: LDHB
Summary
InnateDB Gene IDBG-638957.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDHB
Gene Name L-lactate dehydrogenase B chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019603
Encoded Proteins
L-lactate dehydrogenase B chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111716:
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:88962679-88981219
Strand Forward strand
Band
Transcripts
ENSBTAT00000026118 ENSBTAP00000026118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The citric acid (TCA) cycle and respiratory electron transport pathway
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Disease pathway
Disease pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Pyruvate metabolism pathway
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
Glycolysis / Gluconeogenesis pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
INOH
Methionine Cysteine metabolism pathway
Propanoate metabolism pathway
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_174100 XM_005192229 XM_005201633
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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