Mus musculus Gene: Ldhb
Summary
InnateDB Gene IDBG-196960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldhb
Gene Name lactate dehydrogenase B
Synonyms AI790582; H-Ldh; Ldh-2; LDH-B; LDH-H; Ldh2;
Species Mus musculus
Ensembl Gene ENSMUSG00000030246
Encoded Proteins
lactate dehydrogenase B
lactate dehydrogenase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111716:
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:142490249-142507957
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000032373 ENSMUSP00000032373
ENSMUST00000130817
ENSMUST00000134191 ENSMUSP00000116014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004457 lactate dehydrogenase activity
GO:0004459 L-lactate dehydrogenase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006089 lactate metabolic process
GO:0006096 glycolytic process
GO:0019674 NAD metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Pyruvate metabolism pathway
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Disease pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Abnormal metabolism in phenylketonuria pathway
Pyruvate metabolism pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Disease pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
INOH
Methionine Cysteine metabolism pathway
Propanoate metabolism pathway
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P16125
TrEMBL D3Z7F0 Q5M8R7
UniProt Splice Variant
Entrez Gene 16832
UniGene Mm.391188 Mm.9745
RefSeq NM_008492
OMIM
CCDS CCDS20684
HPRD
IMGT
MGI ID MGI:96763
MGI Symbol Ldhb
EMBL AC142413 AK002257 AK019391 AK131637 BC046755 BC087888 X51905
GenPept AAH46755 AAH87888 BAB21970 BAB31697 BAE20732 CAA36185
RNA Seq Atlas 16832