Version 5.4
Homo sapiens Gene: GC
Summary
InnateDB Gene IDBG-23016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GC
Gene Name group-specific component (vitamin D binding protein)
Synonyms DBP; DBP/GC; GRD3; HEL-S-51; VDBG; VDBP
Species Homo sapiens
Ensembl Gene ENSG00000145321
Encoded Proteins
IDBP-23018
group-specific component (vitamin D binding protein)
IDBP-481138
group-specific component (vitamin D binding protein)
IDBP-479984
group-specific component (vitamin D binding protein)
IDBP-481429
group-specific component (vitamin D binding protein)
IDBP-483238
group-specific component (vitamin D binding protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:71741693-71804041
Strand Reverse strand
Band q13.3
Transcripts
ENST00000273951 ENSP00000273951
ENST00000504199 ENSP00000421725
ENST00000503364
ENST00000513476 ENSP00000426683
ENST00000509740 ENSP00000422664
ENST00000503472
ENST00000505234
ENST00000506245 ENSP00000426718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005499 vitamin D binding
GO:0051183 vitamin transporter activity
GO:1902118 calcidiol binding
Biological Process
GO:0008202 steroid metabolic process
GO:0042359 vitamin D metabolic process
GO:0044281 small molecule metabolic process
GO:0051180 vitamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035540
View Gene Order
ENSBTAG00000013718
Not yet available
Pathways
NETPATH
REACTOME
REACT_13523
Vitamin D (calciferol) metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RF20
UniProt Splice Variant
Entrez Gene 2638
UniGene Hs.418497
RefSeq NM_000583 NM_001204306 NM_001204307
HUGO HGNC:4187
OMIM 139200
CCDS CCDS3550 CCDS56332
HPRD 00749
IMGT
EMBL AC024722
GenPept
RNA Seq Atlas 2638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca