Homo sapiens Gene: GC
Summary
InnateDB Gene IDBG-23016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GC
Gene Name group-specific component (vitamin D binding protein)
Synonyms DBP; DBP/GC; GRD3; HEL-S-51; VDBG; VDBP;
Species Homo sapiens
Ensembl Gene ENSG00000145321
Encoded Proteins
group-specific component (vitamin D binding protein)
group-specific component (vitamin D binding protein)
group-specific component (vitamin D binding protein)
group-specific component (vitamin D binding protein)
group-specific component (vitamin D binding protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:71741693-71804041
Strand Reverse strand
Band q13.3
Transcripts
ENST00000273951 ENSP00000273951
ENST00000504199 ENSP00000421725
ENST00000503364
ENST00000513476 ENSP00000426683
ENST00000509740 ENSP00000422664
ENST00000503472
ENST00000505234
ENST00000506245 ENSP00000426718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005499 vitamin D binding
GO:0051183 vitamin transporter activity
GO:1902118 calcidiol binding
Biological Process
GO:0008202 steroid metabolic process
GO:0042359 vitamin D metabolic process
GO:0044281 small molecule metabolic process
GO:0051180 vitamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Vitamin D (calciferol) metabolism pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P02774
TrEMBL D6RBJ7 D6RF20 D6RF35
UniProt Splice Variant
Entrez Gene 2638
UniGene Hs.418497
RefSeq NM_000583 NM_001204306 NM_001204307
HUGO HGNC:4187
OMIM 139200
CCDS CCDS3550 CCDS56332
HPRD
IMGT
EMBL AC024722 AK223458 AK290827 AK298433 AK309595 AK315853 BC057228 CH471057 L10641 M12654 M17156 S67474 S67476 S67478 S67479 S67480 S67526 S77129 S77130 X03178
GenPept AAA19662 AAA52173 AAA61704 AAB29423 AAD14249 AAD14250 AAH57228 BAD97178 BAF83516 BAF98744 BAG60654 CAA26938 EAX05645
RNA Seq Atlas 2638