Version 5.4
Homo sapiens Gene: NUDT14
Summary
InnateDB Gene IDBG-23192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT14
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183828
Encoded Proteins
IDBP-245394
nudix (nucleoside diphosphate linked moiety X)-type motif 14
IDBP-592450
nudix (nucleoside diphosphate linked moiety X)-type motif 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:105172938-105181323
Strand Reverse strand
Band q32.33
Transcripts
ENST00000339418
ENST00000392568 ENSP00000376349
ENST00000550912
ENST00000551024
ENST00000550002
ENST00000546553 ENSP00000447933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008768 UDP-sugar diphosphatase activity
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002804
View Gene Order
ENSBTAG00000048010
Not yet available
Cross-References
SwissProt O95848
TrEMBL
UniProt Splice Variant
Entrez Gene 256281
UniGene
RefSeq NM_177533
HUGO HGNC:20141
OMIM 609219
CCDS CCDS10000
HPRD 14847
IMGT
EMBL AB087802 AF111170 AL512355 BC041584
GenPept AAD15563 AAH41584 BAC65455
RNA Seq Atlas 256281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca