Version 5.4
Homo sapiens Gene: KIF2A
Summary
InnateDB Gene IDBG-23198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF2A
Gene Name kinesin heavy chain member 2A
Synonyms CDCBM3; HK2; KIF2
Species Homo sapiens
Ensembl Gene ENSG00000068796
Encoded Proteins
IDBP-23200
kinesin heavy chain member 2A
IDBP-294714
kinesin heavy chain member 2A
IDBP-294713
kinesin heavy chain member 2A
IDBP-475899
kinesin heavy chain member 2A
IDBP-476962
kinesin heavy chain member 2A
IDBP-485406
kinesin heavy chain member 2A
IDBP-477351
kinesin heavy chain member 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:62306162-62537249
Strand Forward strand
Band q12.1
Transcripts
ENST00000381103 ENSP00000370493
ENST00000401507 ENSP00000385622
ENST00000407818 ENSP00000385000
ENST00000509663
ENST00000514082 ENSP00000423542
ENST00000504883
ENST00000512541 ENSP00000425411
ENST00000506857 ENSP00000423772
ENST00000512006 ENSP00000421041
ENST00000509624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007067 mitotic nuclear division
GO:0007399 nervous system development
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030154 cell differentiation
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005876 spindle microtubule
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021693
View Gene Order
ENSBTAG00000015022
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt O00139
TrEMBL D6RD93
UniProt Splice Variant
Entrez Gene 3796
UniGene Hs.558351 Hs.653858
RefSeq NM_001243952 NM_001098511 NM_001243953 NM_004520
HUGO HGNC:6318
OMIM 602591
CCDS CCDS58949 CCDS3980 CCDS47216
HPRD 03996
IMGT
EMBL AC016637 AC034242 AC114982 AK302270 AY317140 BC031828 CH471137 EF560716 EF560728 Y08319
GenPept AAH31828 AAP84320 ABQ59026 ABQ59038 BAG63616 CAA69621 EAW51388 EAW51390
RNA Seq Atlas 3796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca