Version 5.4
Homo sapiens Gene: ST8SIA1
Summary
InnateDB Gene IDBG-23371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA1
Gene Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms GD3S; SIAT8; SIAT8-A; SIAT8A; ST8SiaI
Species Homo sapiens
Ensembl Gene ENSG00000111728
Encoded Proteins
IDBP-23373
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-23375
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-238338
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-295241
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-598328
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-602527
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
IDBP-604002
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:22063773-22437041
Strand Reverse strand
Band p12.1
Transcripts
ENST00000261197 ENSP00000261197
ENST00000381424 ENSP00000370832
ENST00000396037 ENSP00000379353
ENST00000404299 ENSP00000384467
ENST00000508924
ENST00000536535
ENST00000544732
ENST00000537795
ENST00000545524
ENST00000545494
ENST00000540824 ENSP00000441707
ENST00000538256 ENSP00000444999
ENST00000541868 ENSP00000440292
ENST00000536558
ENST00000545185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0008284 positive regulation of cell proliferation
GO:0034605 cellular response to heat
GO:0097503 sialylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030283
View Gene Order
ENSBTAG00000000593
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
hsa00601
Glycosphingolipid biosynthesis pathway
hsa00603
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q92185
TrEMBL H0YFU1
UniProt Splice Variant
Entrez Gene 6489
UniGene Hs.408614 Hs.569121 Hs.740059
RefSeq NM_003034 XM_005253470 XM_005253469
HUGO HGNC:10869
OMIM 601123
CCDS CCDS8697
HPRD 03078
IMGT
EMBL AC007544 AC007671 AC053513 AC087318 AC138468 AK290941 AK315340 AY569975 BC117285 BC126162 CH471094 D26360 EU041716 L32867 L43494 X77922
GenPept AAA62366 AAC37586 AAI17286 AAI26163 AAS75783 ABU62753 BAA05391 BAF83630 BAG37739 CAA54891 EAW96468
RNA Seq Atlas 6489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca