InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALB

Summary

InnateDB Gene

IDBG-23584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALB

Gene Name

albumin

Synonyms

ANALBA; FDAH; PRO0883; PRO0903; PRO1341

Species

Homo sapiens

Ensembl Gene

ENSG00000163631

Encoded Proteins

IDBP-23586

albumin

IDBP-293760

albumin

IDBP-371040

albumin

IDBP-371264

albumin

IDBP-476375

albumin

IDBP-483422

albumin

IDBP-480672

albumin

IDBP-479384

albumin

IDBP-806502

albumin

IDBP-806505

albumin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:73397114-73421412

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000295897	ENSP00000295897
ENST00000401494	ENSP00000384695
ENST00000441319	ENSP00000392541
ENST00000415165	ENSP00000401820
ENST00000510166
ENST00000515133
ENST00000514786
ENST00000503124	ENSP00000421027
ENST00000476441	ENSP00000423727
ENST00000509063	ENSP00000422784
ENST00000505649
ENST00000511370	ENSP00000426179
ENST00000507673
ENST00000484992
ENST00000504043
ENST00000486939
ENST00000508932
ENST00000495173
ENST00000621085	ENSP00000483421
ENST00000621628	ENSP00000480485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	173 [view]
Protein-Protein	165 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005504	fatty acid binding
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0015643	toxic substance binding
GO:0016209	antioxidant activity
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0030170	pyridoxal phosphate binding
GO:0051087	chaperone binding

Biological Process

GO:0001895	retina homeostasis
GO:0002576	platelet degranulation
GO:0006810	transport
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0008206	bile acid metabolic process
GO:0009267	cellular response to starvation
GO:0010033	response to organic substance
GO:0015721	bile acid and bile salt transport
GO:0019836	hemolysis by symbiont of host erythrocytes
GO:0030168	platelet activation
GO:0042157	lipoprotein metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0043252	sodium-independent organic anion transport
GO:0044281	small molecule metabolic process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046689	response to mercury ion
GO:0051659	maintenance of mitochondrion location
GO:0055085	transmembrane transport
GO:0070541	response to platinum ion

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031093	platelet alpha granule lumen
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle