Homo sapiens Gene: EPGN
Summary
InnateDB Gene IDBG-24347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPGN
Gene Name epithelial mitogen homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182585
Encoded Proteins
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
epithelial mitogen homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74308473-74315307
Strand Forward strand
Band q13.3
Transcripts
ENST00000332112 ENSP00000330375
ENST00000446430 ENSP00000398415
ENST00000413830 ENSP00000411898
ENST00000502835 ENSP00000423090
ENST00000514968 ENSP00000426550
ENST00000503098 ENSP00000425890
ENST00000502358 ENSP00000426678
ENST00000509145 ENSP00000426630
ENST00000505212 ENSP00000424392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004708 MAP kinase kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:0043406 positive regulation of MAP kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.401237
RefSeq NM_001270989 NM_001270990 NM_001270991 NM_001270992 NM_001270993 XM_005265666 XM_006714170
HUGO
OMIM
CCDS CCDS59475 CCDS59476 CCDS59477 CCDS59478 CCDS59479
HPRD 10866
IMGT
EMBL
GenPept
RNA Seq Atlas