Version 5.4
Homo sapiens Gene: EPGN
Summary
InnateDB Gene IDBG-24347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPGN
Gene Name epithelial mitogen homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182585
Encoded Proteins
IDBP-24349
epithelial mitogen homolog (mouse)
IDBP-371549
epithelial mitogen homolog (mouse)
IDBP-371554
epithelial mitogen homolog (mouse)
IDBP-484204
epithelial mitogen homolog (mouse)
IDBP-475362
epithelial mitogen homolog (mouse)
IDBP-476520
epithelial mitogen homolog (mouse)
IDBP-482203
epithelial mitogen homolog (mouse)
IDBP-484869
epithelial mitogen homolog (mouse)
IDBP-479688
epithelial mitogen homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74308473-74315307
Strand Forward strand
Band q13.3
Transcripts
ENST00000332112 ENSP00000330375
ENST00000446430 ENSP00000398415
ENST00000413830 ENSP00000411898
ENST00000502835 ENSP00000423090
ENST00000514968 ENSP00000426550
ENST00000503098 ENSP00000425890
ENST00000502358 ENSP00000426678
ENST00000509145 ENSP00000426630
ENST00000505212 ENSP00000424392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004708 MAP kinase kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:0043406 positive regulation of MAP kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035020
View Gene Order
ENSBTAG00000004052
Not yet available
Cross-References
SwissProt Q6UW88
TrEMBL
UniProt Splice Variant
Entrez Gene 255324
UniGene Hs.401237
RefSeq NM_001270989 NM_001270990 NM_001270991 NM_001270992 NM_001270993 XM_005265666 XM_006714170
HUGO HGNC:17470
OMIM
CCDS CCDS59475 CCDS59476 CCDS59477 CCDS59478 CCDS59479
HPRD 10866
IMGT
EMBL AK289455 AY358920 DQ235264 DQ235265 DQ235266 DQ235267 DQ235268 DQ235269
GenPept AAQ89279 ABB60043 ABB60044 ABB60045 ABB60046 ABB60047 ABB60048 BAF82144
RNA Seq Atlas 255324

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca