InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pms2

Summary

InnateDB Gene

IDBG-259679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pms2

Gene Name

postmeiotic segregation increased 2 (S. cerevisiae)

Synonyms

AW555130; Pmsl2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079109

Encoded Proteins

IDBP-259683

postmeiotic segregation increased 2 (S. cerevisiae)

IDBP-542806

postmeiotic segregation increased 2 (S. cerevisiae)

IDBP-621501

postmeiotic segregation increased 2 (S. cerevisiae)

IDBP-621502

postmeiotic segregation increased 2 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122512:
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:143909964-143937309

Strand

Forward strand

Band

Transcripts

ENSMUST00000110710
ENSMUST00000110709	ENSMUSP00000106337
ENSMUST00000110707
ENSMUST00000148011	ENSMUSP00000119875
ENSMUST00000141942
ENSMUST00000147910
ENSMUST00000126331
ENSMUST00000154781
ENSMUST00000128153
ENSMUST00000128207
ENSMUST00000170083
ENSMUST00000168085
ENSMUST00000164999	ENSMUSP00000133062
ENSMUST00000172367	ENSMUSP00000132104

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding
GO:0032138	single base insertion or deletion binding
GO:0032407	MutSalpha complex binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0042493	response to drug

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0032389	MutLalpha complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122512

View Gene Order

ENSBTAG00000007364

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03430

Mismatch repair pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228145

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway

REACT_228019

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_228013

Mismatch Repair pathway

REACT_216

DNA Repair pathway

KEGG

hsa03430

Mismatch repair pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

A4QPD7 E9QLM4

UniProt Splice Variant

Entrez Gene

18861

UniGene

Mm.2950 Mm.398563

RefSeq

NM_008886 XM_006504812 XM_006504813 XM_006504814

OMIM

CCDS

CCDS39375

HPRD

IMGT

MGI ID

MGI:104288

MGI Symbol

Pms2

EMBL

AC121917 BC139774

GenPept

AAI39775

RNA Seq Atlas

18861