Version 5.4
Homo sapiens Gene: SOX15
Summary
InnateDB Gene IDBG-26076.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX15
Gene Name SRY (sex determining region Y)-box 15
Synonyms SOX20; SOX26; SOX27
Species Homo sapiens
Ensembl Gene ENSG00000129194
Encoded Proteins
IDBP-26078
SRY (sex determining region Y)-box 15
IDBP-602308
SRY (sex determining region Y)-box 15
IDBP-757783
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7588178-7590170
Strand Reverse strand
Band p13.1
Transcripts
ENST00000250055 ENSP00000355354
ENST00000538513 ENSP00000439311
ENST00000570788 ENSP00000458286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008584 male gonad development
GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0030154 cell differentiation
GO:0043403 skeletal muscle tissue regeneration
GO:0045843 negative regulation of striated muscle tissue development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048627 myoblast development
GO:0070318 positive regulation of G0 to G1 transition
GO:2000288 positive regulation of myoblast proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041287
View Gene Order
ENSBTAG00000005461
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731504 Hs.95582
RefSeq NM_006942
HUGO
OMIM
CCDS CCDS32549
HPRD 03191
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca